• GUARDD-US Team Activates All Sites February 25, 2021

    Congratulations to the GUARDD-US Team for getting all sites activated!

    Congratulations to the Genetic testing to Understand and Address Renal Disease Disparities across the US (GUARDD-US) team for getting all sites activated approximately one month after reaching milestone of 1,000 patients enrolled.

  • IGNITE Diversity & Inclusion Statement November 25, 2020

    The IGNITE Network Leadership calls for Diversity and Inclusion in the conduct of research

    We call on scientific and medical communities to acknowledge and work toward eliminating the injustices perpetuated through all forms of systemic racism and discrimination, both past and present, overt and covert. We condemn eugenic beliefs, policies, and practices. While ancestry has some genetic underpinnings, race is a social construct. Thus, we recognize the consequences of racism and bias on health, healthcare, and research.

    To provide more equitable care ...

  • Fellowship in Genomic Medicine Program Management November 6, 2020

    The National Human Genome Research Institute (NHGRI) invites qualified physicians, physician assistants, nurse practitioners and genetic counselors to apply to the Fellowship in Genomic Medicine Program Management. This is an NIH coalition consisting of the National Human Genome Research Institute (NHGRI), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Minority Health and Health Disparities (NIMHD), and the All of Us Research Program in partnership with the American College of Medical Genetics (ACMG).

    The goal of this fellowship is to increase the pool ...

  • UCSF TRANSPERS Center seeks Asst/Assoc. Prof of Health Services Research, Health Economics August 31, 2020

    UCSF is seeking a faculty member at the Assistant or Associate Professor rank with expertise in health services research, health economics, or a related field. Qualified applicants may also serve as the Assistant Director or Co-Director of the UCSF Center for Translational and Policy Research on Personalized Medicine (TRANSPERS). The Center, founded in 2008, is a global leader in developing objective evidence on the translation of personalized/precision medicine and other new ...

  • New Funding Opportunities for Genetic Counseling Research July 30, 2020

    NHGRI has two new funding opportunities available for genetic counseling research. Visit the NHGRI website for more information.

    Investigator-initiated research on genetic counseling processes and practices (R01, Clinical trial optional)

    Investigator-initiated research on genetic counseling processes and practices (R21, Clinical trial optional)

  • DCRI Think Tank Paper Looks to Future of Pragmatic Clinical Trials July 22, 2020

    Attendees to a January 2019 DCRI Think Tank outlined recommendations for optimizing pragmatic clinical trials and weighing risks and benefits of innovative trial designs.

    Read more from the Duke Clinical Research Institute>>

  • GUARDD-US Enrolls First Patient July 11, 2020GUARDD-US Enrolls First Patient

    IGNITE hit a major milestone on July 10, 2020: The University of Florida randomized the first patient in to the GUARDD-US pragmatic clinical trial.

    Genetic testing to Understand Renal Disease Disparities across the US (GUARDD-US) will investigate the results of apolipoprotein L1 (APOL1) genotyping in an African American population.

    The primary outcome is systolic blood pressure (SBP) at three months comparing patients with high-risk APOL1 variants (positives) versus no high-risk variants (negatives). The co-primary outcome is three-month SBP in positives versus those ...

  • A Crystal Ball for the Decade Ahead January 9, 2020

    With a new decade dawning, Duke Today asked several Duke professors to hypothetically gaze into their crystal balls to tell us what they see happening in the years ahead. CAGPM director Geoff Ginsburg gave his perspective on what he thinks precision medicine will look like in a decade.

    Read more>>

  • Fellowship in Genomic Medicine Program Management January 1, 2020

    The National Human Genome Research Institute (NHGRI) invites qualified physicians, physician assistants, nurse practitioners and genetic counselors to apply to the Fellowship in Genomic Medicine Program Management. This is an NIH coalition consisting of the National Human Genome Research Institute (NHGRI), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Minority Health and Health Disparities (NIMHD), and the All of Us Research Program in partnership with the American College of Medical Genetics (ACMG).

    The goal of this fellowship is to increase the pool ...

  • IGNITE PI Dr. Joshua Denny to serve as new Chief Executive Officer of All of Us research project December 11, 2019

    As CEO, Denny will oversee NIH’s efforts to build one of the largest and most comprehensive precision medicine research platforms in the world, in partnership with a diverse network of awardees and participants.

    Read the announcement from NIH Director Francis Collins, M.D., Ph.D.

  • IGNITE blazes the way for genomic medicine December 3, 2019

    Getting diagnosed with a disease can be scary. Health providers work to find the right treatment plan based on the current standard of care guidelines. But what if in addition to the current evidence, doctors could also factor in each patient’s unique genetic makeup to help them diagnose more quickly and accurately, create a tailored treatment plan, or better yet, learn which patients are at a higher risk for developing specific diseases and employ methods for prevention or earlier detection? ...

  • The Lancet publishes series of 5 papers featuring IGNITE researchers August 5, 2019

    Members of the IGNITE Network were involved in three of the five publications in this series. Genomic Medicine 1: Opportunities, resources and techniques for implementing genomics in clinical care describes the major types and measurement tools of genomic variation that are currently of clinical importance, reviews approaches to interpreting genomic sequence variants, identifies publicly available tools and resources for genomic test interpretation, and discusses several key barriers in using genomic information in routine clinical practice. Genomic Medicine 4: Family health history: ...

  • Andrea Ramirez to present at the AMIA 2019 Annual Symposium August 1, 2019

    Dr. Andrea H. Ramirez will present her research, Extracting Drug Exposure Epochs and Drug Response Outcomes from Electronic Health Records, at the American Medical Informatics Association (AMIA) 2019 Annual Symposium on November 18. Her research was selected out of a record number of submissions to AMIA this year — over 1,200 across all categories!

    Dr. Ramirez is an Assistant Professor of Medicine in the Division of Diabetes, Endocrinology and Metabolism at Vanderbilt University Medical Center. The AMIA 2019 Symposium will be held ...

  • Henry Ong to present at the AMIA 2019 Annual Symposium August 1, 2019

    Dr. Henry Ong will present his research, Extracting Drug Exposure Epochs and Drug Response Outcomes from Electronic Health Records, at the American Medical Informatics Association (AMIA) 2019 Annual Symposium on November 18. His research was selected out of a record number of submissions to AMIA this year — over 1,200 across all categories!

    Dr. Ong is a project manager in the IGNITE Network. He also serves as a project manager at the Vanderbilt Institute for Clinical and Translational Research. The AMIA 2019 ...

  • NIH funds clinical trials using genomics to treat chronic diseases June 5, 2019

    The National Institutes of Health will fund clinical trials to assess the benefits, applicability and efficacy of applying genomic medicine interventions to improve management of diseases such as high blood pressure, depression and chronic pain. The trials are part of the second phase of the Implementing Genomics in Practice (IGNITE) Network with a total investment of $42 million over five years, pending the availability of funds. The trials will begin in 2020. Read more

  • NHGRI publishes overview about IGNITE March 23, 2019

    The Implementing Genomic in Practice (IGNITE) Network was established in 2013 (RFA-HG-12-006RFA-HG-12-007 and RFA-HG-13-004) to develop methods for incorporating genomic information into clinical care and explore the methods for effective implementation, diffusion, and sustainability in diverse clinical settings. The first phase of the network, IGNITE I, was a consortium of collaborative genomic medicine pilot Demonstration Projects designed to demonstrate the feasibility of, and develop methods for, incorporating an individual patient’s genomic findings into his or her clinical care.

    The next ...

  • PHASeR: A collaboration in PGx to help veterans March 22, 2019

    There are about 15 million cancer survivors in the United States; about 400,000 of them are also veterans in the Veterans Affairs (VA) system. As more people survive cancer, their medication needs go beyond their cancer treatment. For veterans, VA physicians hope to bring more personalization to cancer survivorship plans for patients with pharmacogenetic testing. Read more on CAGPM website

  • Evaluating Genomic Medicine Interventions March 21, 2019

    The IGNITE I Network funded six genomic medicine projects. Through varied interventions, Lori Orlando, M.D., and team hypothesized that synergies across projects could be leveraged to better understand participants’ experiences with genomic medicine interventions. The team performed cross-network analyses to identify associations between participant demographics and attitudes toward the intervention, plan to share results, and quality of life. Their results were published online on March 20, 2019, in Molecular Genetics & Genomic Medicine.

  • Ginsburg presented at 1st Macrogen and LKCMedicine Scientific Conference March 20, 2019

    Geoff Ginsburg, M.D., Ph.D., presented at the one-day scientific conference “Applications of Genomic Advances in Healthcare” on March 18, 2019, in Singapore. His presentation was entitled, “Achieving Impact of Precision Medicine Locally, Nationally and Internationally.”

    The conference featured invited speakers from all over the world, including the United States, Finland, Germany, Thailand and Singapore to share their knowledge and experiences on how genomics can be applied to populations, pathways and people.