Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Journal of Personalized Medicine – To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice.
Views Of Primary Care Providers On Testing Patients For Genetic Risks For Common Chronic Diseases
Health Affairs – We surveyed 488 primary care providers in community and academic practices in New York City in the period 2014–16 about their views on genetic testing for chronic diseases.
Race, Genomics and Chronic Disease: What Patients with African Ancestry Have to Say
Journal of Health Care for the Poor and Underserved – To translate genomic discoveries into practice, we gathered information about effects and challenges incorporating genetic risk in clinical care.
The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice
American Journal of Perinatology – Here we provide an overview of the genetics of both pre-gestational and gestational diabetes, followed by a review of monogenic diabetes and associated pregnancy-specific implications.
Family health history: An essential starting point for personalized risk assessment and disease prevention
Personalized Medicine – Family health history (FHH) information is well established as a basis for assessing a patient’s personal disease risk, but is underutilized for diagnosis and making medical recommendations. Epidemiological and genetic information have heightened the value of FHH to an individual’s health. This has motivated the development of new FHH collection tools and strategies for family members, but will require greater awareness and knowledge by both patients and practitioners.
Analytical Validation of a Personalized Medicine APOL1 Genotyping Assay for Nondiabetic Chronic Kidney Disease Risk Assessment. The Journal of molecular diagnostics
The Journal of Molecular Diagnostics – We developed an APOL1 genotyping assay using multiplex allele-specific primer extension, and validated using 58 positive and negative controls.
Personalized medicine in diabetes mellitus: current opportunities and future prospects
Annals of the New York Academy of sciences – Currently, there are 382 million people living with diabetes mellitus around the world, and the total number is predicted to increase by over 50% over the next 20 years. Diabetes mellitus is a spectrum of metabolic disorders characterized by hyperglycemia. Poorly controlled diabetes mellitus can lead to microvascular and macrovascular complications, including kidney failure, blindness, amputation, and cardiovascular disease. Fortunately, medical advances have increased the number of treatment options for diabetes and improved outcomes for many individuals. However, there remains a need to determine the appropriate therapy for each individual, since a significant number of monotherapy treatments fail within 3 years and diabetes-related morbidity and mortality continue.
Effect of Genetic African Ancestry on eGFR and Kidney Disease
Journal of the American Society of Nephrology – Self-reported ancestry, genetically determined ancestry, and APOL1 polymorphisms are associated with variation in kidney function and related disease risk, but the relative importance of these factors remains unclear.
Warfarin Pharmacogenetics
Trends in Cardiovascular Medicine – Since its approval in 1954, warfarin has been widely prescribed for the prophylaxis and treatment of venous thromboembolism and complications associated with atrial fibrillation and cardiac valve replacement. Even with the availability of newer agents shown to be noninferior to warfarin, warfarin remains the most commonly prescribed oral anticoagulant.
Implementation and utilization of genetic testing in personalized medicine
Pharmacogenomics Personalized Medicine – This review aims to summarize the current state of implementing genetic testing for personalized medicine, with an emphasis on clinical pharmacogenetic testing.