Affiliate network members as force amplifiers of genomic medicine research
Future Medicine — The Implementing GeNomics In pracTicE (IGNITE) Network is an NIH-funded network dedicated to advancing the implementation of genomics in healthcare.
Building Evidence for Clinical Use of Pharmacogenomics and Reimbursement for Testing
Advances in Molecular Pathology – In this article, the authors discuss existing data and ongoing efforts to generate evidence in support of genotype-guided therapy approaches and reimbursement for pharmacogenomic testing.
Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy
Pharmacogenetics and Genomics — Hypertension and chronic kidney disease are inextricably linked. Hypertension is a well-recognized contributor to chronic kidney disease progression and, in turn, renal disease potentiates hypertension.
Medication exposure patterns in primary care patients prescribed pharmacogenetically actionable opioids
Qualitative Report – This study’s purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public healthcare system who had been prescribed the pharmacogenetically actionable opioids codeine or tramadol.
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Journal of Personalized Medicine – To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice.
Educational strategies to enable expansion of pharmacogenomics-based care
American Journal of Health-System Pharmacy – This review summarizes requisite pharmacist competencies, educational standards, and the current state of pharmacogenomics education to propose best practice solutions for educators to meet the specific needs and challenges of this complex topic.
Role of genetic testing in patients undergoing percutaneous coronary intervention
Expert Review of Clinical Pharmacology – The present manuscript provides an overview of genetic factors associated with response profiles to platelet P2Y12 receptor inhibitors and their clinical implications, as well as the most recent developments and future considerations on the role of genetic testing in patients undergoing PCI.
Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network
BMC Medical Genomics – The objective of this study was to synthesize data on challenges identified by six diverse projects that are part of a National Human Genome Research Institute (NHGRI)-funded network focused on implementing genomics into practice and strategies to overcome these challenges.
Institutional profile: University of Florida Health Personalized Medicine Program
Pharmacogenomics – We are contributing to the evidence based on outcomes with genotype-guided therapy through pragmatic studies of our clinical implementations. In addition, we have developed a broad array of educational programs for providers, trainees and students that incorporate personal genotype evaluation to enhance participant learning.
The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real‐World Setting
Clinical Translational Science – One of the challenges hindering genomic implementation is the limited data on the outcomes and cost‐effectiveness of genotype‐guided drug therapy. The IGNITE network, consisting of institutions funded in the network and affiliate members, includes a number of institutions that have implemented pharmacogenetic testing to assist with prescribing decisions.