GUARDD-US Clinical Sites

Baylor Scott and White Health Principal Investigator: Heather Kitzman Eskenazi Health Principal Investigator: Michael Eadon Icahn School of Medicine at Mount Sinai Principal Investigator: Carol Horowitz Indiana University Health Principal Investigator: Michael Eadon The Institute for Family Health Principal Investigator: Neil Calman Meharry Medical College Principal Investigator: Rajbir Singh Nashville General Hospital Principal Investigator: Rajbir …

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Protocol for the “Implementation, adoption, and utility of family history in diverse care settings” study

Implementation Science – Risk assessment with a thorough family health history is recommended by numerous organizations and is now a required component of the annual physical for Medicare beneficiaries under the Affordable Care Act. However, there are several barriers to incorporating robust risk assessments into routine care. MeTree, a web-based patient-facing health risk assessment tool, was …

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Toward rapid learning in cancer treatment selection: an analytical engine for practice-based clinical data

Journal of Biomedical Informatics – The promise of leveraging vast medical record data to guide clinical decision making has created growing support for the development of “Rapid Learning Systems” (RLS) that gather and leverage practice-based clinical evidence for real-time clinical decision support. The need for such systems is particularly evident within the field of oncology, where …

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An openly available online tool for implementing the ACMG/AMP standards and guidelines for the interpretation of sequence variants

Genetics in Medicine – We have been using the standards and guidelines to classify variants identified using a next-generation sequencing gene panel for individuals with suspected forms of monogenic diabetes, such as maturity-onset diabetes of the young, as part of the Personalized Diabetes Medicine Program, a member project in the National Human Genome Research Institute–funded IGNITE …

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Emerging Roles for Pharmacists in Clinical Implementation of Pharmacogenomics

Pharmacotherapy – Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We describe roles for pharmacists that emerged in the clinical implementation of genotype-guided clopidogrel therapy in the University of Florida Health Personalized Medicine Program, summarize preliminary program …

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Implementing family health history risk stratification in primary care: Impact of guideline criteria on populations and resource demand

American Journal of Medical Genetics – The Genomic Medicine Model aims to facilitate patient engagement, patient/provider education of genomics/personalized medicine, and uptake of risk‐stratified evidence‐based prevention guidelines using MeTree, a patient‐facing family health history (FHH) collection and clinical decision support (CDS) program. Here we report the number of increased risk (above population‐level risk) patients identified for …

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