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Affiliate network members as force amplifiers of genomic medicine research
Future Medicine — The Implementing GeNomics In pracTicE (IGNITE) Network is an NIH-funded network dedicated to advancing the implementation of genomics in healthcare….
Pharmacogenomics competencies in pharmacy practice: A blueprint for change
Journal of the American Pharmacists Association – The emerging use of genomic data to inform medication therapy populates the medical literature and provides evidence for guidelines in the prescribing information for many medications….
Building Evidence for Clinical Use of Pharmacogenomics and Reimbursement for Testing
Advances in Molecular Pathology – In this article, the authors discuss existing data and ongoing efforts to generate evidence in support of genotype-guided therapy approaches and reimbursement for pharmacogenomic testing….
Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy
Pharmacogenetics and Genomics — Hypertension and chronic kidney disease are inextricably linked. Hypertension is a well-recognized contributor to chronic kidney disease progression and, in turn, renal disease potentiates hypertension….
Medication exposure patterns in primary care patients prescribed pharmacogenetically actionable opioids
Qualitative Report – This study’s purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public…
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Journal of Personalized Medicine – To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility…
Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network
Genetics in Medicine – Here we describe the findings from the National Human Genome Research Institute’s (NHGRI) Implementing GeNomics In pracTicE (IGNITE) Network in identifying key constructs, opportunities, and challenges…
Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework
Genetics in Medicine – This paper describes the implementation outcomes associated with integrating a family health history–based risk assessment and clinical decision support platform within primary care clinics at four diverse…
Views Of Primary Care Providers On Testing Patients For Genetic Risks For Common Chronic Diseases
Health Affairs – We surveyed 488 primary care providers in community and academic practices in New York City in the period 2014–16 about their views on genetic testing for chronic diseases….
Educational strategies to enable expansion of pharmacogenomics-based care
American Journal of Health-System Pharmacy – This review summarizes requisite pharmacist competencies, educational standards, and the current state of pharmacogenomics education to propose best practice solutions for educators to…
Role of genetic testing in patients undergoing percutaneous coronary intervention
Expert Review of Clinical Pharmacology – The present manuscript provides an overview of genetic factors associated with response profiles to platelet P2Y12 receptor inhibitors and their clinical implications, as well as the most…
Developing a Common Framework for Evaluating the Implementation of Genomic Medicine Interventions in Clinical Care: The IGNITE Network’s Common Measures Working Group
Genetics in Medicine – This paper describes the Implementing GeNomics In PracTicE (IGNITE) Network’s efforts to promote: 1) a broader understanding of genomic medicine implementation research; and 2) the sharing of knowledge…
Personalizing antiplatelet prescribing using genetics for patients undergoing percutaneous coronary intervention
Expert Review of Cardiovascular Therapy – This article describes the impact of CYP2C19 genotype on clopidogrel pharmacokinetics, pharmacodynamics, and effectiveness….
IGNITE Network analysis of challenges to implementing genomics in practice featured on GenomeWeb
GenomeWeb – Duke University led this effort to identify key challenges to and potential solutions for implementing genomics in practice based on information from IGNITE’s six member projects. (A free subscription is required to view…
IGNITE Network highlighted at Precision Medicine World Conference 2017
BioQuick News – Duke University’s Dr. Geoffrey Ginsburg, co-chair and speaker at the 2017 Precision Medicine World Conference, presented the IGNITE Network’s achievements and aspirations to advance the implementation of genomics in practice….
Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network
BMC Medical Genomics – The objective of this study was to synthesize data on challenges identified by six diverse projects that are part of a National Human Genome Research Institute (NHGRI)-funded network focused on implementing…
Institutional profile: University of Florida Health Personalized Medicine Program
Pharmacogenomics – We are contributing to the evidence based on outcomes with genotype-guided therapy through pragmatic studies of our clinical implementations. In addition, we have developed a broad array of educational programs…
The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real‐World Setting
Clinical Translational Science – One of the challenges hindering genomic implementation is the limited data on the outcomes and cost‐effectiveness of genotype‐guided drug therapy. The IGNITE network, consisting of institutions…
Cardiovascular Pharmacogenomics – Implications for Patients with Chronic Kidney Disease
Advances in Chronic Kidney Disease – Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. Thus, patients with CKD often require treatment with cardiovascular drugs, such as antiplatelet,…
Race, Genomics and Chronic Disease: What Patients with African Ancestry Have to Say
Journal of Health Care for the Poor and Underserved – To translate genomic discoveries into practice, we gathered information about effects and challenges incorporating genetic risk in clinical care….
High-Throughput Assays to Assess the Functional Impact of Genetic Variants: A Road Towards Genomic-Driven Medicine
Clinical and Translational Science – In this article, we review high‐throughput assays that have been developed to assess a variety of the functional impacts of the variants….
Lessons Learned When Introducing Pharmacogenomic Panel Testing into Clinical Practice
Value in Health – Implementing new programs to support precision medicine in clinical settings is a complex endeavor. We describe challenges and potential solutions based on the Indiana GENomics Implementation: an Opportunity for…
Genetic determinants of P2Y12 inhibitors and clinical implications
Interventional Cardiology Clinics- This review describes genetic contributions to variable response to platelet P2Y12 inhibitors, guidelines for selecting antiplatelet therapy based on genotype, and examples of clinical implementation…
Medical student preparedness for an era of personalized medicine: findings from one US medical school
Personalized Medicine – The objective of this research was to assess medical student preparedness for the use of personalized medicine….
Pharmacists should jump onto the clinical pharmacogenetics train
American Journal of Public Health – This issue of AJHP is a theme issue on precision medicine, focusing on the use of pharmacogenetics in the clinical setting. The articles included provide substantial insight on how and why…
Implementation of inpatient models of pharmacogenetics programs
American Journal of Health-System Pharmacy – The operational elements essential for establishing an inpatient pharmacogenetic service are reviewed, and the role of the pharmacist in the provision of genotype-guided drug therapy…
Pharmacogenomics competencies in pharmacy practice: A blueprint for change
Journal of the American Pharmacists Association – Given the rapidly evolving science, educational needs, and practice models in this area, a standardized competency-based approach to pharmacist education and training in…
Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study
Journal of the American Society of Nephrology – We performed a genome–wide association study among participants in the Chronic Renal Insufficiency Cohort Study to better understand the contribution of genetics to CKD progression….
Effects of Using Personal Genotype Data on Student Learning and Attitudes in a Pharmacogenomics Course
American Journal of Pharmaceutical Education – Although clinical use of pharmacogenomic and genomic data to inform patient care decisions is increasing, it is not yet routine. Coverage of these concepts in health professions…
The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer: A Report of the Association for Molecular Pathology
The Journal of Molecular Diagnostics – Debates surrounding levels and types of evidence needed to properly evaluate the clinical value of molecular diagnostics are increasingly important because the growing body of knowledge,…
The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice
American Journal of Perinatology – Here we provide an overview of the genetics of both pre-gestational and gestational diabetes, followed by a review of monogenic diabetes and associated pregnancy-specific implications….
Clopidogrel pharmacogenetics: from evidence to implementation
Future Cardiology – Clopidogrel is an ideal target for pharmacogenetic intervention for several reasons. First, there is a strong association between genotype, in this case CYP2C19 genotype, and clopidogrel effectiveness [1]….
Implementing Algorithm-Guided Warfarin Dosing in an Ethnically Diverse Patient Population Using Electronic Health Records and Preemptive CYP2C9 and VKORC1 Genetic Testing
Clinical Pharmacology & Therapeutics – To facilitate multiethnic algorithm-guided warfarin dosing using preemptive genetic testing, we developed a strategy that accounts for the complexity of race and leverages electronic…
Family health history: An essential starting point for personalized risk assessment and disease prevention
Personalized Medicine – Family health history (FHH) information is well established as a basis for assessing a patient’s personal disease risk, but is underutilized for diagnosis and making medical recommendations….
Implementing Pharmacogenomics at Your Institution: Establishment and Overcoming Implementation Challenges
Clinical and Translational Science – With advancements in pharmacogenomics research and genotyping technology, implementation of pharmacogenomics into clinical practice is now feasible. The aim of this publication is to serve as…
Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes
Journal of Genetic Counseling – Family health history (FHH) in the context of risk assessment has been shown to positively impact risk perception and behavior change. The added value of genetic risk testing is less certain. The…
Multiplex SNaPshot—a new simple and efficient CYP2D6 and ADRB1 genotyping method
Human Genomics – Reliable, inexpensive, high-throughput genotyping methods are required for clinical trials. Traditional assays require numerous enzyme digestions or are too expensive for large sample volumes. Our objective was…
The Path(way) Less Traveled: A Pathway-Oriented Approach to Providing Information about Precision Cancer Medicine on My Cancer Genome
Translational Oncology – This perspective describes the motivation, development, and implementation of pathway-based content for My Cancer Genome, an online precision medicine knowledge resource describing clinical implications…
The DNA of Pharmacy Education: CAPE Outcomes and Pharmacogenomics
The DNA of Pharmacy Education: CAPE Outcomes and Pharmacogenomics – Pharmacogenomics (PGx) is a rapidly evolving area of precision (i.e., personalized) medicine in which a patient’s genomic information is used to identify the…
Implementation of a Pharmacogenomics Consult Service to Support the INGENIOUS Trial
Clinical Pharmacology & Therapeutics – Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast,…
Genomics in Chronic Kidney Disease: Is this the Path Forward?
Advances in Chronic Kidney Disease – Recent advances in genomics and sequencing technology have led to a better understanding of genetic risk in chronic kidney disease. Genetics could account in part for racial differences in…
CUSTOM-SEQ: a prototype for oncology rapid learning in a comprehensive EHR environment
Journal of the American Medical Informatics Association – As targeted cancer therapies and molecular profiling become widespread, the era of “precision oncology” is at hand….
An openly available online tool for implementing the ACMG/AMP standards and guidelines for the interpretation of sequence variants
Genetics in Medicine – We have been using the standards and guidelines to classify variants identified using a next-generation sequencing gene panel for individuals with suspected forms of monogenic diabetes, such as…
Clinical utility of a Web-enabled risk-assessment and clinical decision support program
Genetics in Medicine – Risk assessment based on the combination of personal and family health history is an effective and essential component of preventive health and is recommended by numerous medical organizations and…
Analytical Validation of a Personalized Medicine APOL1 Genotyping Assay for Nondiabetic Chronic Kidney Disease Risk Assessment. The Journal of molecular diagnostics
The Journal of Molecular Diagnostics – We developed an APOL1 genotyping assay using multiplex allele-specific primer extension, and validated using 58 positive and negative controls….
Physician Response to Implementation of Genotype-Tailored Antiplatelet Therapy
Clinical Pharmacology & Therapeutics – Physician responses to genomic information are vital to the success of precision medicine initiatives. We prospectively studied a pharmacogenomics implementation program for the…
Toward rapid learning in cancer treatment selection: an analytical engine for practice-based clinical data
Journal of Biomedical Informatics – The promise of leveraging vast medical record data to guide clinical decision making has created growing support for the development of “Rapid Learning Systems” (RLS) that gather and leverage…
Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European‐Americans and Egyptians
Clinical and Translational Science – Genotype‐based algorithms that include VKORC1 and CYP2C9 genotypes are less predictive of warfarin dose variability in Africans as opposed to Europeans. Polymorphisms in GGCX, FPGS, or STX1B…
Implementing and Improving Automated Electronic Tumor Molecular Profiling
Journal of Oncology Practice – Oncology practice increasingly requires the use of molecular profiling of tumors to inform the use of targeted therapeutics. However, many oncologists use third-party laboratories to perform tumor…
Integrating electronic health record genotype and phenotype datasets to transform patient care
Clinical Pharmacology & Theraputics – The Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 mandates the development and implementation of electronic health record (EHR) systems across the…
FDA’s Draft Guidance on Laboratory-Developed Tests Increases Clinical and Economic Risk to Adoption of Pharmacogenetic Testing
The Journal of Clinical Pharmacology – The US Food and Drug Administration (FDA) notified Congress July 31, 2014,1 of its intent to regulate laboratory developed tests. These encompass thousands of clinical assays currently used…
Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes
The Journal of Molecular Diagnostics – Pharmacogenetic tests are used to predict or explain an individual’s reaction to drugs by assaying for the presence or absence of known genetic polymorphisms in genes encoding drug…
Pharmacogenomically actionable medications in a safety net health care system
Sage Open Medicine – The implementation of pharmacogenomics is increasingly relevant at the population level. Nearly 70% of Americans take at least one medication and more than 20% take five or more, with spending on medications…
The IGNITE network: a model for genomic medicine implementation and research
BMC Medical Genetics – Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by genotyping, sequencing, family history or other data) to inform clinical…
Guiding Oncology Patients Through the Maze of Precision
Journal of Health Communications – The study results demonstrate that providing information based on health literacy and learning style principles can improve patient understanding of genetic concepts, thus increasing their…
Undiagnosed MODY: Time for Action
Current Diabetes Report – Maturity-Onset Diabetes of the Young (MODY) is a monogenic form of diabetes that accounts for at least 1% of all cases of diabetes mellitus. MODY classically presents as non-insulin requiring diabetes in…
Clinician Perspectives on Using Pharmacogenomics in Clinical Practice
Personalized Medicine – The use of genomic variants to tailor medical therapy is becoming increasingly relevant to routine clinical practice, as medications commonly used in primary care and cardiology practice acquire new…
A prognostic model based on readily available clinical data enriched a preemptive pharmacogenetic testing program
Journal of clinical Epidemiology – A growing body of literature relates human genetic variation to drug response. Currently, more than 100 drugs have pharmacogenomic (PGx) information that affects prescribing in Food and Drug…
Protocol for the “Implementation, adoption, and utility of family history in diverse care settings” study
Implementation Science – Risk assessment with a thorough family health history is recommended by numerous organizations and is now a required component of the annual physical for Medicare beneficiaries under the Affordable Care…
Hypertension pharmacogenomics: in search of personalized treatment approaches
Nature Reviews Nephrology – Cardiovascular and renal diseases are associated with many risk factors, of which hypertension is one of the most prevalent. Worldwide, blood pressure control is only achieved in ~50% of those treated…
CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease
Journal of Neurosurgery – Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated with adverse outcomes in cardiovascular patients, but…
Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations for Test Result Reporting
Clinical Pharmacology & Therapeutics – This manuscript provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting….
Integration of Genomics in Primary Care
The American Journal of Medicine – Because gene-environment interactions are dynamic, the utility of gene-based decision support varies over time. Primary care providers will serve a key role as our patients navigate these changes….
Advancing pharmacogenomics as a component of precision medicine: How, where and who?
Clinical & Pharmacology & Therapeutics – Pharmacogenomics is an important element of precision medicine. Advances in pharmacogenomics implementation have been made but significant barriers remain, including evidence,…
When Participants in Genomic Research Grow Up: Contact and Consent at the Age of Majority
The Journal of Pediatrics – The landscape of pediatric research is becoming more complex. Contemporary research studies, and genome studies in particular, frequently involve a range of research activities. For example, the…
Pharmacogenetics: Using Genetic Information to Guide Drug Therapy
American Family Physician – Clinical pharmacogenetics, the use of genetic data to guide drug therapy decisions, is beginning to be used for medications commonly prescribed by family physicians. However, clinicians are largely…
Pharmacogenomics of Hypertension and Heart Disease
Current Hypertension Report – Heart disease is a leading cause of death in the United States, and hypertension is a predominant risk factor. Thus, effective blood pressure control is important to prevent adverse sequelae of…
Genetics of Resistant Hypertension: a Novel Pharmacogenomics Phenotype
Current Hypertension Report – Resistant hypertension (RHTN), defined as an uncontrolled blood pressure despite the use of multiple antihypertensive medications, is an increasing clinical problem associated with increased…
A conceptual model for translating omic data into clinical action
Journal of Pathology Informatics – Here, we outline a conceptual model for the application of omic data in the clinical context, called “the omic funnel.”…
Attitudes of Clinicians Following Large-Scale Pharmacogenomics Implementation
Pharmacogenomics Journal – Clinician attitudes towards multiplexed genomic testing may be vital to the success of translational programs. We surveyed clinicians at an academic medical center about their views on a large…
Cypiripi: exact genotyping of CYP2D6 using high-throughput sequencing data
Bioinformatics – Response to a large number of clinically prescribed drugs varies significantly among individuals. Although some patients show a good response to a medication, the same treatment might fail in others or cause…
Pharmacogenomics in cardiology – genetics and drug response: 10 years of progress
Future Cardiology – Following completion of the Human Genome Project in 2003, Dr Francis Collins and others on behalf of the National Human Genome Research Institute announced their vision for the future of genomics research. A…
Personalized medicine in diabetes mellitus: current opportunities and future prospects
Annals of the New York Academy of sciences – Currently, there are 382 million people living with diabetes mellitus around the world, and the total number is predicted to increase by over 50% over the next 20 years. Diabetes…
Phenotyping Adverse Drug Reactions: Statin-Related Myotoxicity
AMIA Joint Summits on Translational Science proceedings – This study compares multiple phenotyping approaches for identifying statin-related myotoxicity to highlight potential best practices for identifying adverse drug events….
Report of New Haplotype for ABCC2 Gene
The Journal of Molecular Diagnostics – The ATP-binding cassette, subfamily C [CFTR/MRP], member 2 (ABCC2) gene is a member of the ATP-binding cassette transporters and is involved in the transport of molecules across cellular…
Loss of Heterozygosity at the CYP2D6 Locus in Breast Cancer: Implications for Tamoxifen Pharmacogenetic Studies
Journal of the National Cancer Institute – Loss of functional genetic polymorphisms in CYP2D6 lead to the absence of functional CYP2D6 protein in approximately 5% to 10% of whites (people of European ancestry) and 1% to 2% of…
Incorporating temporal EHR data in predictive models for risk stratification of renal function deterioration
Journal of Biomedical Informatics – In this paper, we describe and evaluate three different approaches that use machine learning to build predictive models using temporal EHR data of a patient….
Effect of Genetic African Ancestry on eGFR and Kidney Disease
Journal of the American Society of Nephrology – Self-reported ancestry, genetically determined ancestry, and APOL1 polymorphisms are associated with variation in kidney function and related disease risk, but the relative…
Emerging Roles for Pharmacists in Clinical Implementation of Pharmacogenomics
Pharmacotherapy – Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We…
Prerequisites to Implementing a Pharmacogenomics Program in a Large Healthcare System
Clinical Pharmacology & Therapeutics – Pharmacogenomics (PGx) technology is advancing rapidly; however, clinical adoption is lagging. The Indiana Institute of Personalized Medicine (IIPM) places a strong focus on translating…
Warfarin Pharmacogenetics
Trends in Cardiovascular Medicine – Since its approval in 1954, warfarin has been widely prescribed for the prophylaxis and treatment of venous thromboembolism and complications associated with atrial fibrillation and cardiac…
Use of a patient-entered Family Health History Tool with Decision Support in Primary Care: Impact of Identification of Increased Risk Patients on Genetic Counseling Attendance
Journal of Genetic Counseling – Although MeTree identified a significant proportion of patients for whom GC was recommended, persistent barriers indicate the need for improved referral processes and patient and physician…
Use of a Patient‐Entered Family Health History Tool with Decision Support in Primary Care: Impact of Identification of Increased Risk Patients on Genetic Counseling Attendance
Journal of Genetic Counseling – Several barriers inhibit collection and use of detailed family health history (FHH) in primary care. MeTree, a computer‐based FHH intake and risk assessment tool with clinical decision support, was…
Meaningful Use of Pharmacogenetics
Clinical Pharmacology & Therapeutics – Although some might wish to see randomized clinical trials (RCTs) for every pharmacogenetic example, we argue that for many examples current evidence supports the implementation of…
Implementation and utilization of genetic testing in personalized medicine
Pharmacogenomics Personalized Medicine – This review aims to summarize the current state of implementing genetic testing for personalized medicine, with an emphasis on clinical pharmacogenetic testing….
The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping
Pharmacogenetics & Genomics – The polymorphic hepatic enzyme CYP2C19 catalyzes the metabolism of clinically important drugs such as clopidogrel, proton-pump inhibitors, and others and clinical pharmacogenetic testing for…
CYP2C19 Polymorphisms and Therapeutic Drug Monitoring of Voriconazole: Are We Ready for Clinical Implementation of Pharmacogenomics?
Pharmacotherapy – Since its approval by the United States Food and Drug Administration in 2002, voriconazole has become a key component in the successful treatment of many invasive fungal infections, including the most common,…
The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update
Clinical Pharmacology & Therapeutics – Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases…
Providing patient education: impact on quantity and quality of family health history collection
Familial Cancer – Patient education improves FHH collection and subsequent risk stratification utilized in providing actionable evidence-based care recommendations for cancer risk management….
Return of Genomic Results to Research Participants: The Floor, the Ceiling, and the Choices In Between
American Journal of Human Genetics – As more research studies incorporate next-generation sequencing (including whole-genome or whole-exome sequencing), investigators and institutional review boards face difficult questions…
Identifying Patients at Increased Disease Risk: Comparing Clinical Judgment and a Clinical Risk Assessment Tool
Journal of Family Medicine & Community Health – There are several barriers to the appropriate use of Family Health History (FHH)for risk management within primary care. Among these is a lack of physician confidence in their…
Warfarin Pharmacogenetics: An Illustration of the Importance of Studies in Minority Populations
Clinical Pharmacology & Therapeutics – Translation of pharmacogenetics to clinical practice is increasingly common. However, most data arise in people of European ancestry, so clinical translation in non-Europeans can be…
Clinical Pharmacogenetics Implementation
American Journal of Medical Genetics – Current challenges exist to widespread clinical implementation of genomic medicine and pharmacogenetics. The University of Florida (UF) Health Personalized Medicine Program (PMP) is a…
Implementing family health history risk stratification in primary care: Impact of guideline criteria on populations and resource demand
American Journal of Medical Genetics – The Genomic Medicine Model aims to facilitate patient engagement, patient/provider education of genomics/personalized medicine, and uptake of risk‐stratified evidence‐based prevention…
Attitudes toward Adopting Genome-Guided Prescribing through Clinical Decision Support
Journal of Personalized Medicine – This study assessed physician attitudes toward adopting genome-guided prescribing through clinical decision support (CDS), prior to enlisting in the Clinical Implementation of Personalized…
Quality of family history collection with use of a patient facing family history assessment tool
BMC Family Practice – Studies have shown that the quality of family health history (FHH) collection in primary care is inadequate to assess disease risk. To use FHH for risk assessment, collected data must have adequate detail…
Development and preliminary evaluation of an online educational video about whole-genome sequencing for research participants, patients, and the general public
Journal of Community Genetics – Structured interviews, including open-ended and closed-ended questions, were conducted with 205 patients in an inner-city hospital outpatient clinic….
Collection of family health history for chronic diseases in primary care
North Carolina Medical Journal – Family health history can predict a patient’s risk for common complex diseases. This project assessed the completeness of family health history data in medical charts and evaluated the…
Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial
BMC Family Practice – Family health history (FHH) is the single strongest predictor of disease risk and yet is significantly underutilized in primary care. We developed a patient facing FHH collection tool, MeTree©, that uses…
Collection of family health history for assessment of chronic disease risk in primary care.
North Carolina Medical Journal – Family health history can predict a patient’s risk for common complex diseases. This project assessed the completeness of family health history data in medical charts and evaluated the…
Development and Validation of a Primary Care-Based Family Health History and Decision Support Program (MeTree)
North Carolina Medicine Journal – Family health history is a strong predictor of disease risk. To reduce the morbidity and mortality of many chronic diseases, risk-stratified evidence-based guidelines strongly encourage the…
The Genomic Medicine Model: An Integrated Approach to Implementation of Family Health History in Primary Care
Personalized Medicine – As an essential tool for risk stratification, family health history (FHH) is a central component of personalized medicine; yet, despite its widespread acceptance among professional societies and its…
The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics
Clinical Pharmacology & Therapeutics – The CLIPMERGE PGx Program is establishing a best-practices infrastructure for implementation of genome-informed prescribing using a biobank-derived clinical cohort, pre-emptive genetic…